Sixteen years ago, Gwen Stacy was killed by the Green Goblin, leaving her boyfriend Peter Parker--also known as the Amazing Spider-Man--to raise their daughter alone. Over time, Peter had minor relationships that never went anywhere concrete, his heart always hurting for Gwen once again. As time passed, Peter became a high school science teacher, still taking photos of himself as Spider-Man for the Daily Bugle.
Now, his daughter May is sixteen and learning about her own Spider-powers, having been born with them. As the Amazing Spider-Girl makes her debut, a new threat rises from OsCorp. Having used alien symbiotes to further their research, several new Spider-Men make their way into the City, each one thinking they're the real Spider-Man. But there is one other surprise for the Parker family that's going to shake up their entire world.
Peter Parker/Spider-Man: Daniel
May Parker/Spider-Girl: Kate
Jake Watson: Daniel
Various Spider-Man Clones: Daniel
Gwen Stacy: Kate
"May, come on!" Peter hollered, shaking his head as he waited for May to come downstairs. "You're gonna be late, and if you're late that means I'm late, and the principal's looking for reasons to write me up for shit. Come on, webhead."
Sixteen years have gone by for PEter since Gwen died, leaving him to raise their daughter on his own, When Aunt May died five years before, Peter knew that his daughter was the only thing left in his life worth waking up for. Now a teacher for Midtown High, he was impatiently waiting for her to come downstairs so tehy could get to the school.